凝血酶原片段1+2 - 血栓性疾病早期诊断分子标志物

凝血酶原片段1+2是凝血酶原激活转化为凝血酶过程中释放的稳定的降解产物,血液中的凝血酶原片段1+2含量可以准确地反映凝血酶早期激活水平,可用于诊断血栓前状态和血栓性疾病以及针对相关疾病及时治疗和监测疗效。

以人凝血酶原片段1+2为例,当凝血途径启动,凝血因子X被激活转变为Xa,Xa可促使凝血酶原中Arg(327)-Thr(328)及Arg(363)-Ile(364)间的肽键同时断裂,释放凝血酶及凝血酶原片段1+2,即Ala(44)-Arg(327)。该凝血酶能够裂解酶原本身,释放出片段1(F1)和片段2(F2),序列分别为Ala(44)-Arg(198), Ser(199)-Arg(327)(见图1)。

凝血酶原片段1+2的研究已经从实验走向临床, Cloud-Clone Corp.针对此片段研制了一系列产品,对于实验室科研客户推出了引物对,重组蛋白,特异性抗体和免疫检测试剂盒等科研产品,工业级客户推出了抗体对以及DIY试剂盒产品,以及针对临床研究客户的IVD原料产品,产品列表如下,欢迎需求的客户咨询及选购。


CATALOG NO.ORGANISM SPECIESPRODUCT NAMEAPPLICATIONS
Increment ServicePGA710Hu01Homo sapiens (Human)Primer Pair for Prothrombin Fragment 1+2 (F1+2)PCR
PGA710Mu01Mus musculus (Mouse)Primer Pair for Prothrombin Fragment 1+2 (F1+2)PCR
PGA710Ra01Rattus norvegicus (Rat)Primer Pair for Prothrombin Fragment 1+2 (F1+2)PCR
ProteinsRPA710Hu01Homo sapiens (Human)Recombinant Prothrombin Fragment 1+2 (F1+2)Positive Control; Immunogen; SDS-PAGE; WB.
RPA710Mu01Mus musculus (Mouse)Recombinant Prothrombin Fragment 1+2 (F1+2)Positive Control; Immunogen; SDS-PAGE; WB.
RPA710Ra01Rattus norvegicus (Rat)Recombinant Prothrombin Fragment 1+2 (F1+2)Positive Control; Immunogen; SDS-PAGE; WB.
AntibodiesPAA710Hu01Homo sapiens (Human)Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC; IP.
LAA710Hu71Homo sapiens (Human)Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC.
MAA710Hu21Homo sapiens (Human)Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC; IP.
LAA710Hu72Homo sapiens (Human)Biotin-Linked Monoclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC.
PAA710Mu01Mus musculus (Mouse)Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC; IP.
PAA710Ra01Rattus norvegicus (Rat)Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC; IP.
LAA710Ra81Rattus norvegicus (Rat)FITC-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC; IF.
LAA710Ra71Rattus norvegicus (Rat)Biotin-Linked Polyclonal Antibody to Prothrombin Fragment 1+2 (F1+2)WB; IHC; ICC.
Assay KitsSEA710HuHomo sapiens (Human)ELISA Kit for Prothrombin Fragment 1+2 (F1+2)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA710HuHomo sapiens (Human)CLIA Kit for Prothrombin Fragment 1+2 (F1+2)Chemiluminescent immunoassay for Antigen Detection.
HEA710HuHomo sapiens (Human)High Sensitive ELISA Kit for Prothrombin Fragment 1+2 (F1+2)Enzyme-linked immunosorbent assay for Antigen Detection.
SEA710MuMus musculus (Mouse)ELISA Kit for Prothrombin Fragment 1+2 (F1+2)Enzyme-linked immunosorbent assay for Antigen Detection.
SCA710RaRattus norvegicus (Rat)CLIA Kit for Prothrombin Fragment 1+2 (F1+2)Chemiluminescent immunoassay for Antigen Detection.
SEA710RaRattus norvegicus (Rat)ELISA Kit for Prothrombin Fragment 1+2 (F1+2)Enzyme-linked immunosorbent assay for Antigen Detection.
SEA710PoSus scrofa; Porcine (Pig)ELISA Kit for Prothrombin Fragment 1+2 (F1+2)Enzyme-linked immunosorbent assay for Antigen Detection.
Antibody PairsPSA710Hu01Homo sapiens (Human)Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1)ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
PSA710Mu01Mus musculus (Mouse)Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1)ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
PSA710Ra01Rattus norvegicus (Rat)Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1)ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
PSA710Po01Sus scrofa; Porcine (Pig)Antibody Pair for Troponin I Type 1, Slow Skeletal (TNNI1)ELISA; CLIA; ELISPOT; Luminex; Immunochromatography and other Immunoassays.
Assay Kit DIY MaterialsKSA710Hu01Homo sapiens (Human)ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2)Main materials for "Do It(ELISA Kit) Yourself"
KSA710Mu01Mus musculus (Mouse)ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2)Main materials for "Do It(ELISA Kit) Yourself"
KSA710Ra01Rattus norvegicus (Rat)ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2)Main materials for "Do It(ELISA Kit) Yourself"
KSA710Po01Sus scrofa; Porcine (Pig)ELISA Kit DIY Materials for Prothrombin Fragment 1+2 (F1+2)Main materials for "Do It(ELISA Kit) Yourself"
IVD Raw MaterialsRSA710Hu21Homo sapiens (Human)Anti-Prothrombin Fragment 1+2 (F1+2) Monoclonal Antibody for IVD Raw MaterialELISA; WB; IHC; Other  Immunoassays.
RSA710Hu01Homo sapiens (Human)Anti-Prothrombin Fragment 1+2 (F1+2) Polyclonal Antibody for IVD Raw MaterialELISA; WB; IHC; Other  Immunoassays.

表1 凝血酶原片段1+2系列产品

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