武汉云克隆科技股份有限公司

Interleukin 11 (IL-11) is a multifunctional cytokine. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses and participate in the regulation of bone cell proliferation and differentiation. Besides, IL-11 has been proved to promote cell proliferation of TF-1 cells. 2x104 TF-1 cells were seeded into a well of 96-well plates and allowed to attach, replaced with various concentrations of recombinant human TRAIL. After incubated for 72 hours, the 96-well plate was read at OD450 nm. The result was shown in Figure1. It was obvious that recombinant IL-11 protein significantly increased cell viability of TF-1 cells. Its EC50 is 0.5677μg/mL.