武汉云克隆科技股份有限公司

粘蛋白5AC(MUC5AC)多克隆抗体

Polyclonal Antibody to Mucin 5 Subtype AC (MUC5AC)

TBM; MUC5; LeB; Oligomeric Mucus/Gel-Forming; Mucin 5,Subtypes A And C,Tracheobronchial/Gastric; Gastric mucin; Lewis B blood group antigen; Major airway glycoprotein

  • 粘蛋白5AC(MUC5AC)多克隆抗体产品包装(模拟)
  • 粘蛋白5AC(MUC5AC)多克隆抗体产品包装(模拟)
  • Certificate通过ISO 9001、ISO 13485质量体系认证

特异性

该抗体是针对MUC5AC的兔多克隆抗体。在免疫组织化学染色和免疫印迹实验中能识别MUC5AC。

用法

免疫印迹：0.2-2µg/mL;1:250-2500
免疫组织化学：5-20µg/mL;1:25-100
免疫细胞化学：5-20µg/mL;1:25-100
最佳稀释倍数最终由用户决定。

储存

经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

赠品

相关产品

编号适用物种：Bos taurus; Bovine (Cattle，牛)应用(仅供研究使用，不用于临床诊断！)
PAA756Bo01粘蛋白5AC(MUC5AC)多克隆抗体WB; IHC; ICC; IP.

参考文献

杂志参考文献
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Investigative Ophthalmology & Visual ScienceEntrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification[PubMed: 21421863]
Cell & Molecular Biology Role of aquaporin 5 in antigen-induced airway inflammation and mucous hyperproduction in mice[PubMed: 20550619]
Mucosal ImmunologyHomeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13[Nature: 201082a]
European Journal of PharmacologyNaringin attenuates EGF-induced MUC5AC secretion in A549 cells by suppressing the cooperative activities of MAPKs-AP-1 and IKKs-IκB-NF-κB signaling pathways[ScienceDirect: S0014299912005523]
PLoS OneBaicalein Reduces Airway Injury in Allergen and IL-13 Induced Airway Inflammation[PubMed: PMC3639905]
Respiratory ResearhPyocyanin-induced mucin production is associated with redox modification of FOXA2[PubMed: PMC3765780]
SurgeryA novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC)[Pubmed: 24468034]
Biochemical and Biophysical Research CommunicationsThe human cathelicidin LL-37 enhances airway mucus production in chronic obstructive pulmonary disease[Pubmed:24291709]
Journal of ProteomicsProteomic analysis of cancer and mesothelial cells reveals an increase in Mucin 5AC during ovarian cancer and peritoneal interaction[Pubmed:24726482]
Experimental Lung ResearchThe human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway[Pubmed:24901072]
Surgery.?Assessment of bile and serum mucin5AC in cholangiocarcinoma: Diagnostic performance and biologic significance[Pubmed:25151557]
Allergology InternationalLeukotriene E 4 induces MUC5AC release from human airway epithelial NCI-H292 cells[Pubmed:25838093]
RespirologySecreted mucins and airway bacterial colonization in non-CF bronchiectasis[PubMed: 26172851]
SIsabela Casagrande Jeremias[Teses: Disponiveis]
American Thoracic Society International Conference AbstractsMucin Secretion In Asthmatics With Osmotic Airway Hyperresponsiveness[doi:10.1164]
Deletion Polymorphism and Chronic Obstructive Pulmonary DiseaseReCavia (Guinea pig )lation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells[Pubmed:27075970]
Int J Clin Exp MedThe influence of long-term corneal contact lens wearing on the stability and quality of tear film in Qinghai[files:ijcem0020163.pdf]
Ann Am Thorac SocAirway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization[doi:10.1513]
Sci Rep Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers[Pubmed:27297822]
Cytokine. Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasalepithelial cells.[pubmed:27776277]
J Virol. Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective.[pubmed:28275196]
Respiratory Physiology & NeurobiologyPeroxiredoxin 6 suppresses Muc5ac overproduction in LPS-induced airway inflammation through H2O2-EGFR-MAPK signaling pathway.[pubmed:27884794]
Journal of Immunology ResearchBeneficial effects of prebiotic Saccharomyces cerevisiae mannan on allergic asthma mouse models[pubmed:28835901]
BASIC INVESTIGATIONEfficacy of Sodium Hyaluronate in Murine Diabetic Ocular Surface Diseases[pubmed:28644234]
International ImmunopharmacologyClarithromycin inhibits TNF-α-induced MUC5AC mucin gene expression via the MKP-1-p38MAPK-dependent pathway[pubmed:28550735]
Секреторно-экссудативная реакция слизистой носа на воздействие холодного воздуха у больных бронхиальной астмой[10.20538/1682-0363-2017-2-146-158]
Cellular MicrobiologyAn adherent mucus layer attenuates the genotoxic effect of colibactin. [pubmed:29156489]
Respiratory ResearchIL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells[pubmed:28931396]
ChemotherapyOxytetracycline Inhibits Mucus Secretion and Inflammation in Human Airway Epithelial Cells.[pubmed:28578323]
AllergyTh2 cytokines orchestrate the secretion of MUC 5 AC and MUC 5B in IL‐5 positive chronic rhinosinusitis with nasal polyps[Pubmed:29802623]
European Journal of Pharmacology Salvianolic acid B improves airway hyperresponsiveness by inhibiting MUC5AC overproduction associated with Erk1/2/P38 signaling[Pubmed:29382534]
InflammationPlantamajoside Inhibits Lipopolysaccharide-Induced MUC5AC Expression and Inflammation through Suppressing the PI3K/Akt and NF-κB Signaling Pathways in …[Pubmed:29349683]
Pulmonary Pharmacology and TherapeuticsIn vivo and in vitro investigation of anti-inflammatory and mucus-regulatory activities of a fixed combination of thyme and primula extracts[Pubmed:29698781]
European Respiratory SocietyProfiling of healthy and asthmatic airway smooth muscle cells following IL-1β treatment: a novel role for CCL20 in chronic mucus hyper-secretion[Pubmed:29946002]
Clinical and Experimental OphthalmologyDevelopment of a highly sensitive and reliable enzyme-linked immunosorbent assay for MUC5aC in human tears extracted from schirmer strips[Pubmed: 30214141]
international journal of biological macromoleculesIncreased expression of long non-coding RNA SNHG16 correlates with tumor progression and poor prognosis in non-small cell lung cancer[Pubmed: 30287374]
Journal of Investigative MedicineThe characteristics and clinical significance of mucin levels in bronchoalveolar lavage fluid of patients with interstitial lung disease[Pubmed: 30573494]
PhytomedicineRegulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion[Pubmed: 31301536]
Scientific ReportsRegional comparison of Goblet cell number and Area in exposed and covered Dry eyes and their Correlation with Tear MUC5AC[Pubmed: 32076085]
Eur J PharmacolTLR3 inhibitor and tyrosine kinase inhibitor attenuate cigarette smoke/poly I: C-induced airway inflammation and remodeling by the EGFR/TLR3/MAPK …[Pubmed: 33068589]
journal of ethnopharmacologyEffective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K …[Pubmed: 32344236]
Less Airway Inflammation and Goblet Cell Metaplasia in an IL-33-Induced Asthma Model of Leptin-Deficient Obese Mice[]
Exp Mol PatholThe regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal?¡­[33285209]
FEBS Open BioPorphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells[33332733]
Cell RepGeneration of functional conjunctival epithelium, including goblet cells, from human iPSCs[33535050]