武汉云克隆科技股份有限公司

基质金属蛋白酶13(MMP13)重组蛋白

Recombinant Matrix Metalloproteinase 13 (MMP13)

CLG3; Collagenase 3

  • 基质金属蛋白酶13(MMP13)重组蛋白产品包装(模拟)
  • 基质金属蛋白酶13(MMP13)重组蛋白产品包装(模拟)
  • Certificate通过ISO 9001、ISO 13485质量体系认证

序列

用法

PBS或其它。

储存

避免反复冻融。2-8°C不超过一个月，-80°C不超过12个月。

稳定性

热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。

相关产品

编号适用物种：Canis familiaris; Canine (Dog，犬)应用(仅供研究使用，不用于临床诊断！)
RPA099Ca01基质金属蛋白酶13(MMP13)重组蛋白Positive Control; Immunogen; SDS-PAGE; WB.
PAA099Ca01基质金属蛋白酶13(MMP13)多克隆抗体WB; IHC; ICC; IP.

参考文献

杂志参考文献
Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseHyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression[ScienceDirect: S0925443911001323]
Journal of Physiology and BiochemistryProtective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats[SpringerLink: h875w73171w2147w]
FEBS JournalAdenosine A2a Receptor Activation and Hyaluronan Fragment Inhibition Reduce Inflammation in Mouse Articular Chondrocytes Stimulated with Il-1beta[Wiley: source]
Arthritis & RheumatismInterruption of glycosphingolipid synthesis enhances osteoarthritis development in mice[Wiley: source]
GeneHyaluronan in part mediates IL-1beta-induced inflammation in mouse chondrocytes by up-regulating CD44 receptors[ScienceDirect: S0378111911007347]
PLoS ONEA Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches[Plosone: Source]
Arthritis RheumatolIdentification of Alpha 2 Macroglobulin (A2M) as a master inhibitor of cartilage degrading factors that attenuates post-traumatic osteoarthritis progression.[Pubmed: 24578232]
Arthritis & RheumatologyIdentification of Alpha 2 Macroglobulin (A2M) as a master inhibitor of cartilage degrading factors that attenuates post-traumatic osteoarthritis progression[Onlinelibrary: art.38576]
Thromb Haemost.Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke[Pubmed:24671655]
Arthritis & RheumatolIdentification of α2-Macroglobulin as a Master Inhibitor of Cartilage-Degrading Factors That Attenuates the Progression of Posttraumatic Osteoarthritis[Pubmed:24578232]
Inflammation.?Systemic and Flap Inflammatory Response Associates with Thrombosis in Flap Venous Crisis[Pubmed:25448261]
Cellular Physiology and BiochemistryInverse Regulation of Early and Late Chondrogenic Differentiation by Oxygen Tension Provides Cues for Stem Cell-Based Cartilage Tissue Engineering[Pubmed:25632940]
Osteoarthritis and CartilageDepletion of gangliosides enhances cartilage degradation in mice[Sciencedirect:S1063458413010364]
Biol ResThe role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis[PubMed: 26578310]
PLoS OneInterleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression[PubMed: 26474296]
Cell Mol Immunol Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica[Pubmed:27157496]
Scientific ReportsChondrogenic Potential of Peripheral Blood Derived Mesenchymal Stem Cells Seeded on Demineralized Cancellous Bone Scaffolds[pubmed:27821864]
International Journal of Contemporary Medical ResearchMatrix Metalloproteinase-13 (MMP-13): A Novel Tumor Marker for Diagnosis of Breast Carcinoma[uploads:7]
Scientific ReportsOlive and grape seed extract prevents post-traumatic osteoarthritis damages and exhibits in vitro anti IL-1β activities before and after oral consumption.[pubmed:27640363]
Photodermatol Photoimmunol Photomed. Protective effects of Aloe sterols against UVB‐induced photoaging in hairless mice[pubmed:27995657]
Molecular Medicine ReportsIcariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells[pubmed:28447732]
bmc musculoskeletal disordersStrontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis.[pubmed:28187731]
Journal of Cellular PhysiologyIncreased Chondrogenic Potential of Mesenchymal Cells From Adipose Tissue Versus Bone Marrow‐Derived Cells in Osteoarthritic In Vitro Models[pubmed:27739057]
BMC Musculoskeletal DisordersEstablishment of rat ankle post-traumatic osteoarthritis model induced by malleolus fracture[pubmed:29149841]
Journal of Applied Animal ResearchHypoxia enhances secretion of matrix metalloproteinases in bovine dermal fibroblasts:an in vitro approach to bovine digital dermatitis [10.108:09712119.2017.1335208]
Alexandria Journal of MedicineL-Carnitine ameliorates knee lesions in mono-iodoacetate induced osteoarthritis in rats[10.1016:j.ajme.2016.03.002]
National Journal of Integrated Research in Medicine Matrix Metalloproteinase-13 Can Be Used As an Independent Diagnostic and Prognostic Marker for Breast Carcinoma.[AN=123116960]
Molecular Medicine ReportsEffects of GGCX overexpression on anterior cruciate ligament transection-induced osteoarthritis in rabbits[Pubmed:29257344]
Journal of Applied Animal Research Hypoxia enhances secretion of matrix metalloproteinases in bovine dermal fibroblasts: an approach to bovine digital dermatitis[10.1080:09712119.2017.1335208]
Osteoarthritis CartilageCoordinated existence of multiple gangliosides is required for cartilage metabolism[Pubmed: 30471358]
PLoS OneCo-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis[Pubmed: 30939166]
PathobiologySuppressed Expression but Not Activity of Collagenases MMP-1 and MMP-13 in Human Renal Carcinoma[Pubmed: 31129674]
BoneDAla2GIP antagonizes H2O2-induced chondrocyte apoptosis and inflammatory factor secretion[Pubmed: 31283994]
Food & FunctionA dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese …[]
JOURNAL OF CELLULAR BIOCHEMISTRYTeneligliptin inhibits IL‐1β‐induced degradation of extracellular matrix in human chondrocytes[Pubmed: 32162384]
Bone ResearchEffects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis[Pubmed: 32047705]
Scientific ReportsMatrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis[Pubmed: 31980722]
NutrientsChondroprotective Properties of Human-Enriched Serum Following Polyphenol Extract Absorption: Results from an Exploratory Clinical Trial[Pubmed: 31888255]
Nature CommunicationsVulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13[Pubmed: 32807790]
Molecular Medicine ReportsMicroRNA-1 promotes cartilage matrix synthesis and regulates chondrocyte differentiation via post-transcriptional suppression of Ihh expression[Pubmed: 32705199]
RESEARCH SQUAREExperimental Observation of the Sequence of Tibial Plateau Chondrocyte and Matrix Degeneration in Spontaneous Osteoarthritis in Guinea Pigs[]
Hyaluronic Acid versus Alpha-2-Macroglobulin Intra-Articular Injections for Amelioration of Knee Posttraumatic Osteoarthritis: A Rat Model[]
Loss of autophagy in tibial plateau chondrocytes causes increased apoptosis of chondrocytes in spontaneous osteoarthritis of guinea pigs[]
Food FunctUndenatured type II collagen prevents and treats the osteoarthritis and motor function degradation in T2DM patients and db/db mice[33890588]
NutrientsMetabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo …[34444810]
Sci RepLiraglutide, a glucagon-like peptide 1 receptor agonist, exerts analgesic, anti-inflammatory and anti-degradative actions in osteoarthritis[Pubmed:35091584]