骨保护素(OPG)重组蛋白
Recombinant Osteoprotegerin (OPG)
TNFRSF11B; TNFRSF11-B; OCIF; OPG; TR1; Tumor Necrosis Factor Receptor Superfamily Member 11b; Osteoclastogenesis Inhibitory Factor
- 编号RPA108Mu01
- 物种Mus musculus (Mouse，小鼠)相同的名称，不同的物种。
- 来源原核表达
- 宿主E.coli
- 内毒素水平<1.0EU/µg(LAL法测定)
- 亚细胞定位分泌
- 预测分子量59.4kDa
- 实际分子量59kDa(差异分析请参阅说明书)
- 片段与标签Glu22~Val281 with N-terminal His and GST Tag
- 缓冲液成份20mM Tris, 150mM NaCl缓冲液（pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300）
- 性状冻干粉
- 纯度> 80%
- 等电点7.6
- 应用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，请参见活性蛋白。 - 下载英文说明书 中文说明书
- 规格10µg50µg200µg1mg5mg
- 价格¥ 840¥ 2100¥ 4200¥ 12600¥ 31500
- 欲了解实际交易价格和更多情况，请与当地经销商联系!
产品包装(模拟)
产品包装(模拟)
Figure. SDS-PAGE
通过ISO 9001、ISO 13485质量体系认证
序列
用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存
避免反复冻融。2-8°C不超过一个月，-80°C不超过12个月。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定，具体方法如下：在37°C孵育48小时，没有显著的降解或者沉淀产生。保质期内，在适当的条件下存储，损失率低于5%。
增值服务
相关产品
| 编号 | 适用物种：Mus musculus (Mouse，小鼠) | 应用(仅供研究使用，不用于临床诊断！) |
| EPA108Mu61 | 骨保护素(OPG)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA108Mu01 | 骨保护素(OPG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA108Mu02 | 骨保护素(OPG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| PAA108Mu01 | 骨保护素(OPG)多克隆抗体 | WB; IHC; ICC; IP. |
| PAA108Mu02 | 骨保护素(OPG)多克隆抗体 | WB; IHC; ICC; IP. |
| MEA108Mu | 骨保护素(OPG)检测试剂盒(酶联免疫吸附试验法,小样本) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEA108Mu | 骨保护素(OPG)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA108Mu | 骨保护素(OPG)检测试剂盒(化学发光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| LMA108Mu | 骨保护素(OPG)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. |
| OGA108Mu02 | 骨保护素(OPG)基因敲除小鼠 | 动物实验，阴性对照。 |
参考文献
| 杂志 | 参考文献 |
| Pharmacology | Protective Effect of Amlodipine on Rat Bone Tissue after Orchidectomy[Karger: 335491] |
| Endocrine Pharmacology | Protective effect of atorvastatin on bone tissue in orchidectomised male albino Wistar rats[ScienceDirect: S0014299912000659] |
| PLOS One | Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone Erosions[PubMed: PMC3483160] |
| International Journal of Oral and Maxillofacial Surgery | The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model[Pubmed: 23522850] |
| American Journal of Orthodontics and Dentofacial Orthopedics | OPG and RANKL levels around miniscrew implants during orthodontic tooth movement[Pubmed: 23910201] |
| AGE | Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells[Pubmed: 24687841] |
| Food Science & Nutrition | Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7[Onlinelibrary: fsn3.109] |
| Food Sci Nutr. | Effects and mechanisms of 8‐prenylnaringenin on osteoblast MC3T3‐E1 and osteoclast‐like cells RAW264. 7[Pubmed:Pmc4221832] |
| J Neurol Sci. | The effect of topiramate and lamotrigine on rat bone mass, structure and metabolism.[Pubmed:24629477] |
| Journal of Investigative Surgery | Effect of Nicotine on RANKL and OPG and Bone Mineral Density[Pubmed:24830656] |
| Int J Mol Med. | Effects of icariin on the regulation of the OPG?RANKL?RANK system are mediated through the MAPK pathways in IL?1β?stimulated human SW1353 chondrosarcoma …[Pubmed:25270538] |
| Clinical and Experimental Pharmacology and Physiology | Carvedilol promotes neurological function, reduces bone loss and attenuates cell damage after acute spinal cord injury in rats[Pubmed:25424914] |
| Journal of Colloid and Interface Science | Strontium and zoledronate hydroxyapatites graded composite coatings for bone prostheses[Pubmed:25706198] |
| Int J Clin Exp Pathol | A novel model of bisphosphonate-related osteonecrosis of the jaw in rats[PubMed: 26191212] |
| IJHS(international journal of health sciences) | Relation of Osteoprotegerin, Visfatin and Ghrelin to Metabolic Syndrome in Type 2 Diabetic Patients[PubMed: 26309431] |
| Pharmacology | Effect of Mirtazapine on Rat Bone Tissue after Orchidectomy[PubMed: 25871861] |
| Experimental And Therapeutic Medicine | Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway[Pubmed:27347050] |
| Bone | The effects of strength training and raloxifene on bone health in aging ovariectomized rats[Pubmed:26812611] |
| Scienze Biomediche | Effetti del laser a bassa dose su cellule osteoblastiche[INCERTIPARENTI_SERENA_TESI.pdf] |
| journal of biomedical materials research part a | RAW 264.7 co-cultured with ultra-high molecular weight polyethylene particles spontaneously differentiate into osteoclasts: an in vitro model of periprosthetic osteolysis.[pubmed:27667508] |
| Nutrition. | Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats.[pubmed:27908549] |
| PLoS One. | Extracorporeal shock waves alone or combined with raloxifene promote bone formation and suppress resorption in ovariectomized rats.[pubmed:28158228] |
| Sci Rep. | Skeletal Site-specific Effects of Zoledronate on in vivo Bone Remodeling and in vitro BMSCs Osteogenic Activity.[pubmed:28139685] |
| Journal of Biomaterials and Tissue Engineering | Modification and Characterization of Polyethylene Glycolated Decellularized Porcine Aortic Heart Valve with Osteoprotegerin[art00007] |
| Japanese Society for Bone and Mineral Research | Allogeneic yet major histocompatibility complex‑matched bone marrow transplantation in mice results in an impairment of osteoblasts and a significantly reduced trabecular bone[article:10.1007] |
| ONCOLOGY LETTERS | Assessment of bone metabolism and biomechanical properties of the femur, following treatment with anastrozole and letrozole in an experimental model of menopause[ol.2017.6596] |
| Journal of Biomedical Materials Research | RAW 264.7 co-cultured with ultra-high molecular weight polyethylene particles spontaneously differentiate into osteoclasts: an in vitro model of periprosthetic osteolysis[10.1002/jbm.a.35912] |
| Oncotarget | Mesenchymal stem cells inhibit RANK-RANKL interactions between osteoclasts and Th17 cells via osteoprotegerin activity.[pubmed:29137353] |
| Asian Journal of Biomedical and Pharmaceutical Sciences | A Water Extract of Benefiting-Bone Capsule Improves Osteoporosis via Transcriptional and Translational Regulation of Key Factors in Notch and Wnt/ò-catenin Signaling Pathways in Ovariectomized Rats[ISSN 2249 – 622X] |
| ACS Applied Materials and Interfaces | Enhanced Osseointegration of Porous Titanium Modified with Zeolitic Imidazolate Framework-8.[pubmed:28696091] |
| Journal of Clinical Periodontology | Peroxisome proliferator‐activated receptor γ plays dual roles on experimental periodontitis in rats[Pubmed:29574908] |
| Journal of Functional Foods | Effect of long-term administration of mangiferin from on bone metabolism in ovariectomized rats[10.1016:j.jff.2018.04.048] |
| Macromolecular Bioscience | Strontium‐Substituted Hydroxyapatite‐Gelatin Biomimetic Scaffolds Modulate Bone Cell Response[Pubmed:29877029] |
| Journal of Ethnopharmacology | Effects of water extract from epimedium on neuropeptide signaling in an ovariectomized osteoporosis rat model[Pubmed:29705515] |
| International Journal of Molecular Medicine | Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice[Pubmed:29717766] |
| Journal of Bone and Mineral Metabolism | Allogeneic yet major histocompatibility complex-matched bone marrow transplantation in mice results in an impairment of osteoblasts and a significantly reduced …[Pubmed:28766138] |
| Journal of Bone and Mineral Metabolism | Therapeutic effect of icariin combined with stem cells on postmenopausal osteoporosis in rats[Pubmed:28681147] |
| Pharmacology | Effects of Amlodipine on Bone Metabolism in Orchidectomised Spontaneously Hypertensive Rats[Pubmed:29898457] |
| Experimental and Therapeutic Medicine | Liraglutide exerts a bone‑protective effect in ovariectomized rats with streptozotocin‑induced diabetes by inhibiting osteoclastogenesis[Pubmed:29805533] |
| Bone | The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats[Pubmed: 30208342] |
| Bone Research | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts[Pubmed: 30455992] |
| Bone | Development and characterization of supramolecular calcitonin assembly and assessment of its interactions with the bone remodelling process[Pubmed: 30797058] |
| RSC Advances | Biofunctionalization of decellularized porcine aortic valve with OPG-loaded PCL nanoparticles for anti-calcification[Doi: 10.1039/C9RA00408D] |
| ANTICANCER RESEARCH | Promoter Methylation Down-regulates Osteoprotegerin Expression in Ovarian Carcinoma[Pubmed: 31092428] |
| BIOSCIENCE REPORTS | IL-38 restrains inflammatory response of collagen-induced arthritis in rats via SIRT1/HIF-1α signaling pathway[Pubmed: 32347300] |
| Oxid Med Cell Longev | Long-Term Administration of Abacavir and Etravirine Impairs Semen Quality and Alters Redox System and Bone Metabolism in Growing Male Wistar Rats[34373766] |
| Biomed Pharmacother | Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis[Pubmed:35453007] |
| Medicina (Kaunas) | Plasma Concentrations of New Biochemical Markers of Atherosclerosis in Patients with Dyslipidemia—A Pilot Study[Pubmed:35743980] |
| Journal of Orthopaedic Translation | Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …[] |