细胞因子信号转导抑制因子3(SOCS3)重组蛋白
Recombinant Suppressors Of Cytokine Signaling 3 (SOCS3)
ATOD4; CIS3; Cish3; MGC71791; SOCS-3; SSI-3; SSI3; Cytokine-inducible SH2 protein 3; STAT-induced STAT inhibitor 3
- 编号RPB684Ra01
 - 物种Rattus norvegicus (Rat,大鼠)相同的名称,不同的物种。
 - 来源原核表达
 - 宿主E.coli
 - 内毒素水平<1.0EU/µg(LAL法测定)
 - 亚细胞定位分泌
 - 预测分子量26.1kDa
 - 实际分子量29kDa(差异分析请参阅说明书)
 - 片段与标签Met1~Leu225 with N-terminal His Tag
 - 缓冲液成份20mM Tris, 150mM NaCl缓冲液(pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300)
 - 性状冻干粉
 - 纯度> 95%
 - 等电点7.8
 - 应用Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白,请参见活性蛋白。 - 下载英文说明书 中文说明书
 - 规格10µg50µg200µg1mg5mg
 - 价格¥ 960¥ 2400¥ 4800¥ 14400¥ 36000
 - 欲了解实际交易价格和更多情况,请与当地经销商联系!
 
序列

用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存
避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。
增值服务
相关产品
| 编号 | 适用物种:Rattus norvegicus (Rat,大鼠) | 应用(仅供研究使用,不用于临床诊断!) | 
| RPB684Ra01 | 细胞因子信号转导抑制因子3(SOCS3)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. | 
| PAB684Ra01 | 细胞因子信号转导抑制因子3(SOCS3)多克隆抗体 | WB; IHC; ICC; IP. | 
| LAB684Ra71 | 细胞因子信号转导抑制因子3(SOCS3)多克隆抗体(生物素标记) | WB; IHC; ICC. | 
| MAB684Ra21 | 细胞因子信号转导抑制因子3(SOCS3)单克隆抗体 | WB; IHC; ICC; IP. | 
| SEB684Ra | 细胞因子信号转导抑制因子3(SOCS3)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. | 
| MEB684Ra | 细胞因子信号转导抑制因子3(SOCS3)检测试剂盒(酶联免疫吸附试验法,小样本) | Enzyme-linked immunosorbent assay for Antigen Detection. | 
| LMB684Ra | 细胞因子信号转导抑制因子3(SOCS3)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. | 
参考文献
| 杂志 | 参考文献 | 
| The Journal of Biological Chemistry | Human primary keratinocytes show a restricted ability to up-regulate suppressor of cytokine signaling (SOCS)3 compared to autologous macrophages[Jcb: 280370] | 
| The Journal of Biological Chemistry | Human Primary Keratinocytes Show Restricted Ability to Up-regulate Suppressor of Cytokine Signaling (SOCS)3 Protein Compared with Autologous Macrophages[PubMed: PMC3323061] | 
| Journal of Reproductive Immunology | What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility?[Pubmed: 24368037] | 
| The Journal of Immunology | Alveolar Epithelial Cell–Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation[Pubmed:27183597] | 
| Scientific Reports | The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway[pubmed:28970500] | 
| Journal of Immunological Methods | Endogenous peroxidases in sputum interfere with horse-radish peroxidase-based ELISAs.[pubmed:29154772] | 
| Turkish Journal Of Medical Sciences | The impact of plasma SOCS3 levels and endometrial leukocytes on unexplained infertility[Pubmed:29914245] | 
| Novel trajectories of Bromocriptine antidiabetic action: Leptin-IL-6/JAK2/p-STAT3/SOCS3, p-IR/p-AKT/GLUT4, PPARγ/Adiponectin, Nrf2/PARP-1, and GLP-1[articles:10.3389] | |
| JCI Insight | Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics[Pubmed: 31619584] | 
| European Journal of Pharmacology | Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways[Pubmed: 32067934] | 
| FASEB JOURNAL | Resident alveolar macrophage‐derived vesicular SOCS3 dampens allergic airway inflammation[Pubmed: 32030817] | 
| molecular immunology | SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection[Pubmed: 32645550] | 
| Experimental and Therapeutic Medicine | Changes and clinical significance of serum inflammatory factors in the treatment of pregnancy hypertension syndrome with magnesium sulfate combined with …[Pubmed: 32742411] | 
| NEUROCHEMICAL RESEARCH | Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage[33755856] | 
| BIOMEDICINE & PHARMACOTHERAPY | Potential contribution of ELISA and LFI Assays to assessment of the oxidative stress condition based on 8-oxodG biomarker[33957564] | 



