Good News! 云克隆产品引用文献累计数量突破10000篇!

Banner 文献 2018-1.jpg

2018年伊始,小C团队开展了新一轮的文献搜集工作。为了查找杂志中的“颜如玉”,办公室的小伙伴们不舍昼夜地忙碌,真是为伊消得人憔悴啊!功夫不负有心人,此次整理收获还是棒棒哒~


                                                                                                        咳咳,敲黑板啦~

此次共收集新文献2029篇!   


其中来自《Nature》旗下的文献有11篇,我们在此只展示其中1篇来自《Nature Medicine》的文章,影响因子有29.88哦!


Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23.

ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.

Lagares D1, Ghassemi-Kakroodi P2, Tremblay C2, Santos A1, Probst CK1, Franklin A1, Santos DM1, Grasberger P1, Ahluwalia N1, Montesi SB1, Shea BS1, Black KE1, Knipe R1, Blati M2, Baron M3, Wu B4, Fahmi H2, Gandhi R4, Pardo A5, Selman M6, Wu J2, Pelletier JP2, Martel-Pelletier J2, Tager AM1, Kapoor M2,4,7,8.

Abstract

Maladaptive wound healing responses to chronic tissue injury result in organ fibrosis. Fibrosis, which entails excessive extracellular matrix (ECM) deposition and tissue remodeling by activated myofibroblasts, leads to loss of proper tissue architecture and organ function; however, the molecular mediators of myofibroblast activation have yet to be fully identified. Here we identify soluble ephrin-B2 (sEphrin-B2) as a new profibrotic mediator in lung and skin fibrosis. We provide molecular, functional and translational evidence that the ectodomain of membrane-bound ephrin-B2 is shed from fibroblasts into the alveolar airspace after lung injury. Shedding of sEphrin-B2 promotes fibroblast chemotaxis and activation via EphB3 and/or EphB4 receptor signaling. We found that mice lacking ephrin-B2 in fibroblasts are protected from skin and lung fibrosis and that a disintegrin and metalloproteinase 10 (ADAM10) is the major ephrin-B2 sheddase in fibroblasts. ADAM10 expression is increased by transforming growth factor (TGF)-β1, and ADAM10-mediated sEphrin-B2 generation is required for TGF-β1-induced myofibroblast activation. Pharmacological inhibition of ADAM10 reduces sEphrin-B2 levels in bronchoalveolar lavage and prevents lung fibrosis in mice. Consistent with the mouse data, ADAM10-sEphrin-B2 signaling is upregulated in fibroblasts from human subjects with idiopathic pulmonary fibrosis. These results uncover a new molecular mechanism of tissue fibrogenesis and identify sEphrin-B2, its receptors EphB3 and EphB4 and ADAM10 as potential therapeutic targets in the treatment of fibrotic diseases.



                                                                                            激动的心,颤抖的手,小C要宣布:

云克隆产品引用文献累计数量突破10000篇!



看到这个成绩,您可能会说厉害了我的小C!但是我们不骄傲!借着圣瓦伦丁节(St. Valentine's Day),小C也大声向亲爱的您再次告白:


                                                                                                  科研道路从来不是坦途,


                                                                                                  无论有多少艰难险阻,


                                                                                                  小C会一直陪伴您,


                                                                                                  直到您拥有了想要的一切,


                                                                                                  当然,包括我。  

                                     

                                                ——云克隆