表皮调节素(EREG)重组蛋白
Recombinant Epiregulin (EREG)
EPR; ER; Proepiregulin
- 编号RPB945Hu02
- 物种Homo sapiens (Human,人)相同的名称,不同的物种。
- 来源原核表达
- 宿主E.coli
- 内毒素水平<1.0EU/µg(LAL法测定)
- 亚细胞定位细胞膜, 分泌
- 预测分子量9.0kDa
- 实际分子量11kDa(差异分析请参阅说明书)
- 片段与标签Val63~Leu108 with N-terminal His Tag
- 缓冲液成份20mM Tris, 150mM NaCl缓冲液(pH8.0, 含有1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose和Proclin300)
- 性状冻干粉
- 纯度> 95%
- 等电点6.5
- 应用Positive Control; Immunogen; SDS-PAGE; WB.
 如果需要有生物活性的蛋白,请参见活性蛋白。
- 下载英文说明书 中文说明书
- 规格10µg50µg200µg1mg5mg
- 价格¥ 1080¥ 2700¥ 5400¥ 16200¥ 40500
- 欲了解实际交易价格和更多情况,请与当地经销商联系!
序列

用法
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
储存
避免反复冻融。2-8°C不超过一个月,-80°C不超过12个月。
稳定性
热稳定性以损失率显示。损失率是由加速降解试验决定,具体方法如下:在37°C孵育48小时,没有显著的降解或者沉淀产生。保质期内,在适当的条件下存储,损失率低于5%。
增值服务
相关产品
| 编号 | 适用物种:Homo sapiens (Human,人) | 应用(仅供研究使用,不用于临床诊断!) | 
| RPB945Hu02 | 表皮调节素(EREG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. | 
| RPB945Hu04 | 表皮调节素(EREG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. | 
| RPB945Hu01 | 表皮调节素(EREG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. | 
| RPB945Hu03 | 表皮调节素(EREG)重组蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. | 
| PAB945Hu02 | 表皮调节素(EREG)多克隆抗体 | WB | 
| PAB945Hu01 | 表皮调节素(EREG)多克隆抗体 | WB | 
| PAB945Hu04 | 表皮调节素(EREG)多克隆抗体 | WB; IHC | 
| MAB945Hu22 | 表皮调节素(EREG)单克隆抗体 | WB; IHC; ICC; IP. | 
| SEB945Hu | 表皮调节素(EREG)检测试剂盒(酶联免疫吸附试验法) | Enzyme-linked immunosorbent assay for Antigen Detection. | 
| SCB945Hu | 表皮调节素(EREG)检测试剂盒(化学发光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. | 
| LMB945Hu | 表皮调节素(EREG)等多因子检测试剂盒(流式荧光发光法) | FLIA Kit for Antigen Detection. | 
参考文献
| 杂志 | 参考文献 | 
| British Journal of Cancer | Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells[Nature: 2012103] | 
| J Pharmacol Exp Ther. | Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.[Pubmed: 24309559] | 
| Molecular Carcinogenesis | The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines[Pubmed:23625689] | 
| Am J Physiol Gastrointest Liver Physiol. | Epiregulin promotes the emergence and proliferation of adult liver progenitor cells.[Pubmed:24812054] | 
| European Review for Medical and Pharmacological Sciences | Epiregulin-loaded PLGA nanoparticles increase human keratinocytes proliferation: preliminary data[pubmed:27383296] | 
| Oncotarget | Overexpression of a functional calcium-sensing receptor dramatically increases osteolytic potential of MDA-MB-231 cells in a mouse model of bone metastasis through epiregulin-mediated osteoprotegerin downregulation[PMC5593575] | 
| American journal of respiratory cell and molecular biology | Potential Involvement of the Epidermal Growth Factor Receptor Ligand Epiregulin and Matrix Metalloproteinase-1 in Pathogenesis of Chronic Rhinosinusitis[pubmed:28398769] | 
| International Journal of Cancer | Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer[Pubmed: 30252132] | 
| Epiregulin is released from intervertebral disks and induces spontaneous activity in pain pathways[Doi: 10.1097/PR9.0000000000000718] | |
| Cell proliferation | Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway[Pubmed: 31454111] | 
| International Journal of Molecular Sciences | Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts[Pubmed: 31771279] | 
| Neoplasia | Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine[Pubmed: 33212364] | 
| Reprod Sci | Compromised Cumulus-Oocyte Complex Matrix Organization and Expansion in Women with PCOS[34748173] | 
| Tissue and Cell | MiR-192-5p suppresses M1 macrophage polarization via epiregulin (EREG) downregulation in gouty arthritis[34715618] | 



